01 MAY 2019

8.15 Registration

Opening Session

8.45 Welcome Session
Béatrice Vergier, CHU Bordeaux and Bordeaux University, Inserm U1053 BaRITOn
Jean-Philippe Merlio, CHU Bordeaux and Bordeaux University, Inserm U1053 BaRITOn
Manuel Sobrinho Simões, i3S/IPATIMUP & Faculty of Medicine of the University of Porto & CHUSJ
Rui Henrique, Portuguese Oncology Institute of Porto & ICBAS

Session I – The Cancer Ecosystem: applications in pathology

Chairs: Fátima Carneiro and Jean-Philippe Merlio

9.00  Tumour infiltrating lymphocytes and PD-L1 in breast carcinomas
Fernando Schmitt

9.20 Clinical, histological and molecular predictors of metastatic melanoma responses to anti-PD-1 immunotherapy
M. Darmon and B. Vergier

9.40 Impact of STK11/LKB1 tumour suppressor gene mutations on the response of bronchopulmonary carcinomas to immunotherapy
H. Bégueret and D. Cappelen

10.00  The microbiome and gastric cancer: beyond Helicobacter pylori

Céu Figueiredo

10:20 Coffee break

Session II – The Cancer Ecosystem: perspectives in pathology research

Chairs: Leonor David and David Cappelen

10:40  DICER1 germline alterations in papillary thyroid carcinoma cases from TCGA database
Sule Canberk

11:00 Proteomic profiling of liver CK7+/CK20- (A)DKs on FFPE blocks: primary versus metastatic?
C. Laffon, A.A. Raymond and B. Le Bail

11:20 The “genvironment” and the major role of epigenetics in human germ cell tumours: looking for disease biomarkers and novel treatment options
João Lobo

11:40 Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms
S. Croce

Session III – Hot topics in pathology: Battle of controversies

Chairs: Catarina Eloy and Brigitte Le-Bail

12:00Is p16 a decisive surrogate marker to diagnose HPV related carcinomas?
Con: Carla Bartosch
Pros: José Manuel Lopes

12:25Is NGS necessary to assess mutations (or is FISH still necessary)?
Con: José Carlos Machado
Pros: Jean-Philippe Merlio

12:50 Lunch break + Group Photo

Session IV – Interactive Cyto-histologic Slide Seminar – Part I

Chairs: Manuel Sobrinho Simões and Béatrice Vergier

15:00 Coffee break

Session IV – Interactive Cyto-histologic Slide Seminar – Part II

Chairs: Mariana Afonso and Sabrina Croce

Organizing Committee
Bordeaux Team

BELLEANNÉE Geneviève, CHU Bordeaux
CAPPELLEN David, CHU and Inserm U1053
CROCE Sabrina, Bergonié Institute and Inserm U1218
LE-BAIL Brigitte, CHU Bordeaux and Inserm U1053
MERLIO Jean-Philippe, CHU Bordeaux and Inserm U1053
VERGIER Béatrice, CHU Bordeaux and Inserm U1053

Porto Team

Manuel Sobrinho Simões, i3S/IPATIMUP & CHUSJ & FMUP
Fátima Carneiro, i3S/IPATIMUP & CHUSJ & FMUP
Carla Bartosch, IPO & ICBAS
Elisabete Rios, i3S/IPATIMUP & CHUSJ & FMUP
António Polónia, i3S/IPATIMUP
Catarina Costa, CHUSJ & FMUP
Tiago Costa Pereira, CHUSJ

26th Porto Cancer Meeting 2019

The Cancer Ecosystem: From Research to Pathology and Treatment
& 5th Joint Meeting Porto-Bordeaux 2019

02 MAY 2019

09.00 Welcome Session, Manuel Sobrinho-Simões, i3S/ Ipatimup & Mário Barbosa, i3S

Session 1: Microbiome in Cancer

Chairs: Fátima Carneiro, CHSJ and Céu Figueiredo, i3S

9.15-9.45 Role of the gut microbiome in causing, detecting and treating colorectal cancer
Paul O’Toole, School of Microbiology, University College Cork, Ireland

9.45-10.15  Interplay between immune contexture and gut microbiota in human colorectal cancer
Giandomenica Iezzi,
 Ente Ospedaliero Cantonale and Università della Svizzera Italiana, Switzerland

10.15-10.45 Coffee-break

10.45-11.15 Gut microbiota, can we improve the outcome of cancer immunotherapy
Meriem Messaoudene, Centre de Recherche du Centre Hospitalier de l’Universite de Montreal, Canada

11.15-11.30 SELECTED TALK: Gastric cancer is characterized by a dysbiotic microbiome
Rui Ferreira, i3S – Instituto de Investigação e Inovação em Saúde/ Ipatimup, Portugal

SPECIAL SESSION: A tribute to society 

Chair: José Carlos Machado, i3S

11.30-12.00 How the contributions from society have improved the clinical management and molecular understanding of paediatric brain tumours         

Jorge Lima, i3S – Instituto de Investigação e Inovação em Saúde, Portugal

Maria João Gil da Costa, Department of Paediatric Oncology, Centro Hospitalar de São João, Portugal

12.00-13.00 Lunch

13.00-14.30 Speed Talks | Auditorium Corino de Andrade

Chairs: Patrícia Oliveira, i3S and Hugo Caires, i3S

Session 2: Tumour Microenvironment

Chairs: Rui Henrique, IPO-Porto and Raquel Seruca, i3S

14.30-15.00 The crosstalk between stem-like cancer cells and the tumor microenvironment
Joana Paredes,
i3S – Instituto de Inovação em Saúde / Ipatimup, Portugal

15.00-15.30 Metabolic interactions in chronic lymphocytic leukemia
Dimitrios Mougiakakos, Department of Medicine 5 – Hematology and Clinical Oncology, University of Erlangen, Germany

15.30-16.00 Coffee-break

16.00-16.30 Neoadjuvant chemotherapy elicits a pro-metastatic cascade through extracellular vesicles
Ioanna Keklikoglou
, Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Switzerland

16.30-16.45 SELECTED TALK: Pancreatic Cancer Stem Cells Coordinate an Organized Exosomes Communication Network that Dysregulates the Hippo Pathway Contributing to Pancreatic Cancer Progression
Carolina Ruivo, i3S – Instituto de Investigação e Inovação em Saúde and Instituto de Ciências Biomédicas de Abel Salazar, Portugal

20.00 Meeting Dinner

03 MAY 2019

Session 3: Inflammation and Cancer

Chairs: Guilherme Macedo, CHSJ and José Carlos Machado, i3S

9.00-9.30 “Inflammation and homeostasis” to understand “Inflammation and cancer”
Francisco Real
, Spanish National Cancer Research Centre / Universitat Pompeu Fabra, Spain

09.30-10.00Immune-metabolism in Liver Cancer and Cancer Cachexia
Erwin Wagner, Medical University Vienna, Austria

10.00-10.30 Coffee Break

10.30-11.00 On the role of innate and adaptive immune cells in fatty liver disease and subsequent liver cancer
Mathias Heikenwälder
, Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany

11.00-11.15 SELECTED TALK: Crosstalk of signaling hubs and chronic inflammation in human tumorigenesis
Carla Lopes, Instituto Gulbenkian de Ciência, Portugal

11.15-12.30 Speed Talks | Auditorium Corino de Andrade

Chairs: Sérgia Velho, i3S and Stefan Mereiter, i3S

12.30-14.00 Lunch and Poster viewing

Session 4: Immunotherapy

Chairs: Júlio Oliveira, IPO-Porto and Sónia Melo, i3S

Suppression and Tumor Progression
Wei Guo
, Department of Biology, School of Arts & Sciences, University of Pennsylvania, USA

14.30-15.00 Neoadjuvant immunotherapy – the pathway to biomarker identification and personalized therapy
Christian Blank
, Netherlands Cancer Institute, the Netherlands

15.00-15.30 Coffee-break

16.00-16.30 Signal Finding Platform trials: optimizing drug development
Pablo Martinez Rodriguez,
Medimmune, LLC, USA

16.30-16.45 SELECTED TALK: Homologous recombination deficiency in metastatic gastric cancer
Nuno Sousa
, IPO-Porto, Portugal