Glycosylation in tumour biology and its clinical implications
The cancer bittersweet portrait

11-12 May 2023



11 May 2023

12 May 2023

9:00 – 9:20 Welcome Session

Manuel Sobrinho-Simões, Claudio Sunkel and Celso Reis

Session 1: Glycosylation in Cancer

Chairs: Fátima Carneiro (CHSJ/FMUP/i3S) & Henrique Duarte (i3S)

9:20 – 9:50 Overview of glycosylation in gastrointestinal cancer and clinical implications

Celso Reis, IPATIMUP/i3S University of Porto, Portugal.


9:50 – 10:30 Glycosylation-dependent mechanisms that regulate neoplastic transformation

Susan Bellis, Comprehensive Cancer Center, University of Alabama, USA

10:30-11:00 Coffee break


Chairs: Catarina Gomes (i3S) & Lúcio Lara Santos (IPO)

11:00 – 11:40 Mind the GAGs in gastric cancer

Ana Magalhães, IPATIMUP/i3S University of Porto, Portugal

11:40 – 12:10 Selected talk

Cracking the ErbB2 Sugar Code in Gastric Cancer – A Bittersweet Functional Target
Henrique Duarte
, IPATIMUP/i3S University of Porto, Portugal

12:10 – 12:45 Speed talks

Chairs: Rita Matos, i3S & Daniela Freitas, i3S

12:45 – 14:15 Lunch break

Session 2: Glycans in cancer molecular and cell biology

Chairs: Carmen Jerónimo (IPO, ICBAS) & Ana Magalhães (ICBAS/i3S)


14:15 – 14:55 Role of Notch Glycosylation in Cancer

Robert Haltiwanger, Complex Carbohydrate Research Center, Georgia, USA

14:55 – 15:25 – Selected talk

GALA: a Glycopathway regulating tissue remodelling
Frédéric Bard, CRCM, France

15:25 – 15:55 – Selected talk

New insights into the role of sialylation in breast cancer immune evasion and immunotherapy resistance
Stefan Mereiter, IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria

16:00-16:30 Coffee break

Special Session

Chair: Celso A Reis (i3S)

16:30 – 17:20 Galectins: novel glycocheckpoints and therapeutic targets in cancer

Gabriel Rabinovich, Instituto de Biología y Medicina Experimental, CONICET and University of Buenos Aires, Argentina

20:00 Meeting Dinner

Session 3: Glycosylation in tumor microenvironment and immune modulation

Chairs: Maria Oliveira (i3S) & Joana Gomes (i3S)


9:00 – 9:40 Cell surface heparan sulfate as a multifunctional modulator and therapeutic target of breast cancer progression

Martin Götte, University of Münster, Germany


9:40 – 10:30 Targeting cancer-associated sialylation for cancer immunotherapy

Heinz Läubli, University Hospital Basel, Switzerland

10:30 – 11:00 Coffee break

11:00 – 11:30 Selected talk

Glycoproteogenomics Characterization of the CD44 Splicing Code in Bladder Cancer Towards Precision Oncology
José Alexandre Ferreira, IPO-Porto, Portugal

11:30 – 12:00 Selected talk

Monensin disrupts the synthesis of SLeX in tumors and influences its malignant features
Catarina Gomes, i3S/ IPATIMUP, Portugal

12:00 – 12:40 Speed talks

Chairs: Rita Matos, i3S & Filipe Pinto, i3S

12:40 – 14:15 Lunch break

Session 4: Translational Research and glycan-based clinical applications

Chairs: Salomé Pinho (i3S) & Júlio Oliveira (IPOP)


14:15 – 14:55 Glycoimmunology: sugars on the fuss for improved immunotherapies?

Paula Videira, Glycoimmunology Group, Nova University Lisbon, Portugal & CellmAbs Biopharmaceuticals

14:55– 15:25 Selected talk

Glycomimetics as next generation of precision therapeutics in cancer: the discovery of Fucosyltransferase-Specific Inhibition
Barbara Richichi, Department of Chemistry ‘Ugo Schiff’, University of Florence, Italy

15:25 – 15:40 Closing session

Chair: Celso A Reis & André Albergaria (i3S)