20 May

10.00-10.15 Welcome Session
Joana Paredes, i3S & Manuel Sobrinho-Simões, Ipatimup/ i3S & Claudio Sunkel, i3S

Session 1: Cancer Cell Heterogeneity & Plasticity

Chairs: José Carlos Machado, i3S & Carmen Jerónimo, IPOP

10.15-10.45 Breast cancer heterogeneity and resistance to endocrine therapy

Maria Vivanco
CIC bioGUNE, Basque Research & Technology Alliance (BRTA), Bilbao, Spain

10.45-11.15 Mechanisms regulating EMT tumor transition states

Ievgenia Pastushenko
Université Libre de Bruxelles (ULB), Bruxelles, Belgium

11.15-11.30 Selected Talk: Mutational landscape and Clonal Architecture of Oral Cancer

Inês Sequeira, Queen Mary University of London, London, United Kingdom

11.30-12.00 Tumor plasticity implications in breast cancer immunity

Toni Celià-Terrassa
Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain

12.00-12.15 15-minutes Break

Special Session: Cancel_Stem Symposium

Chairs: Joana Paredes, i3S & Raquel Seruca, i3S

12.15-12.35 Using a humanized P-cadherin fly model to uncover key players involved in Cancer Stem-like Cell activity

Florence Janody
Instituto Gulbenkian Ciência (IGC), Oeiras & i3S, Porto

12.35-12.55 Gastric cancer stem cells identified by a SOX2 reporter system

Raquel Almeida
i3S, Porto, Portugal

2.55-13.15 Targeting drug combinations with nanomedicine-based strategies

João Nuno Moreira
Center for Neurosciences and Cell Biology (CNBC), Coimbra, Portugal

13.15-15.00 Lunch Break & Poster View

14.30-15.00 Satellite Seminar: Addressing the true complexity of cancer with 10x Genomics single cell and spatial multiomics

Session 2: Stemness & Tumor Microenvironment

Chairs: Ana Sofia Ribeiro, i3S & Maria José Oliveira, i3S

15.00-15.30 Mechano-perception in the tumour microenvironment

Chris Madsen
Cancer and Matrix Remodelling – Lund University, Lund, Sweden

15.30-16.00 Targeting the metastatic niche

Janine Erler
Biotech Research and Innovation Centre (BRIC), Copenhagen, Denmark

16.00-16.15 Selected Talk: Cancer-Stem cells exosomes coordinate intratumor communication and drive YAP1 activation

Carolina F. Ruivo, i3S, IPATIMUP; Institute of Biomedical Sciences Abel Salazar, Porto, Portugal 

16.15-16.45 force-dependent regulation of stemness promotes tumor risk and aggression

Valerie Weaver
Centre for Bioengineering & Tissue Regeneration – UCSF, San Francisco, USA

21 May

Session 3: Invasion, Dissemination & Metastasis

Chairs: Joana Paredes, i3S & Cláudia Faria, IMM

9.30-10.00 Molecular mechanisms of cancer cell invasion: focus on P-cadherin and flotillins

Cécile Gauthier-Rouviére
CRBM, University of Montpellier – CNRS, Montpellier, France

10.00-10.15 Selected Talk: Osteosarcoma-derived secretome mimics the effects of a primary tumor during pre-metastatic niche formation

Sara Almeida, CIBIT/ICNAS – Institute for Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal 

10.15-10.45 Heterogeneity of the Macro-Metastasis Parenchyma Interface (MMPI) during metastatic organ colonization and its impact on prognosis, pathophysiology and treatment

Tobias Pukrop
University Hospital Regensburg, Regensburg, Germany

10.45-11.00 Selected Talk: Ubiquitin Conjugating Enzymes promote aggressive metastatic brain disease and decrease patients’ survival 

Eunice PaisanaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal 

11.00-11.15 15-minutes Break

11.15-11.45 Strategies to challenge brain metastasis lethality in mice and human

Manuel Valiente
Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

11.45-12.00 Selected Talk: Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis

Ana Sofia Ribeiroi3S, IPATIMUP, Porto, Portugal 

12.00-12.30 Biology and Vulnerabilities of Circulating Tumor Cells

Nicola Aceto
Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland

12.30-14.00 Lunch Break & Poster View

Session 4: Cancer Stemness – Clinical Translation

Chairs: Júlio Oliveira, IPOP & Ricardo Leão, FMUC

14.00-14.30 Replication repair deficiency, Obligatory mutation accumulation and its effect on cancer initiation and response to immunotherapy; Lessons from hereditary cancer syndromes

Uri Tabori
The Hospital for Sick Children

14.30-15.00 Targeting cancer stem cells in hormone resistance breast cancer

Bruno Simões
Division of Cancer Sciences, University of Manchester, UK

15.00-15.15 Selected Talk: Discovery of novel colon cancer stem cell inhibitors by high-throughput screening in tumour spheres

Marta Afonso, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal

15.15-15.45 Harnessing replication stress for novel breast cancer stem cell therapy

Christophe Ginestier
Cancer Research Center of Marseille (CRCM), Marseille, France

15.45-16.00 Award Communication & Closing Session
Joana Paredes, i3S & Jorge Lima, i3S & André Albergaria, i3S