Extracellular Vesicles, Cell Communication and Cancer
Time to Prick the Bubble

12 May 2022

8.50-9.00 Welcome

Sónia Melo, i3S & Manuel Sobrinho-Simões, Ipatimup/ i3S & Claudio Sunkel, i3S

Session 1: EVs and Novel Therapeutic Approaches in Cancer

Chairs: Bruno Sarmento, i3S & Júlio Oliveira, IPOP

Keynote Talk

9.00-9.45 Biology and clinical translation of Exosomes in cancer

Raghu Kalluri, MD Anderson Cancer Center, Houston, TX, USA

9.45-10.15 Coffee Break

10.15-10.45 Vascular heterogeneity informs organotropic metastasis

Valerie LeBleu, Feinberg school of medicine and Kellogg school of management, northwestern university, Chicago, IL, USA; MD Anderson cancer center, Houston, TX, USA

10.45-11.15 Building an Engineered exosome based nucleic acid delivery system from bench to bedside

Sriram Sathyanarayanan, Codiak Biosciences, Boston, USA

11.15-11.30 Selected Talk: Osteosarcoma-derived exosomes as imaging tools for early detection of lung metastasis

Sara Filipa Fernandes de Almeida, CIBIT/ICNAS – Institute for Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal

11.30-13.00 Speed Talks

13.00-14.00 Lunch Break

Session 2: EVs and Metastasis

Chairs: Carolina Ruivo, i3S & José Carlos Machado, i3S

14.00-14.30 Influence of tumor-derived small extracellular vesicles in premetastatic niche formation (Online)

Hector Peinado, National Spanish Cancer Center (CNIO), Spain

14.30-15.00 High spatio-temporal tracking of metastasis (and EVs) in vivo

Jacky Goetz, IGBMC, France

Special Session: How Cancer Spreads

Chairs: Manuel Sobrinho-Simões, Ipatimup, i3S & José Carlos Machado, i3S

15.00-16.00  Epigenetic Control of Tumor Progression (Online)

Robert Weinberg, MIT, Boston, USA

20.00 Dinner at Rio Douro

13 May 2022

Session 3: EVs in Cancer Biology

Chairs: Sónia Melo, i3S & Cláudio Sunkel, i3S 

Keynote Talk

9.00-9.45 Intravital microscopy of the role of extracellular vesicles in therapy responses (The talk will not be broadcasted)

Jacco van Rheenen, NKI, The Netherlands

9.45-10.15 Functional Heterogeneity of Cancer-Derived Extracellular Vesicles

Dolores Di VizioCedars-Sinai, LA, USA

10.15-10.45 Coffee Break

10.45-11.15 Decoding the Pancreatic Intratumor Communication Network (EVNet)

Sónia Melo, i3S, Porto, Portugal

11.15-11.30 Selected Talk: Resistance to EGFR inhibitors in lung cancer occurs through horizontal transfer and is associated with increased caveolins expression

Susana Junqueira Neto, i3S / IPATIMUP – Instituto de Patologia e Imunologia Molecular da Universidade do Porto; FMUP Faculty of Medicine, University of Porto, Porto, Portugal

11.30-11.45 Selected Talk: Deciphering the glycan code of extracellular vesicles in gastric cancer cell communication

Ana Magalhães, i3S / IPATIMUP – Instituto de Patologia e Imunologia Molecular da Universidade do Porto; ICBAS – Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal

11.45-13.15 Speed Talks

13.15-14.15 Lunch Break

Session 4: EVs and Immune Response in Cancer

Chairs: Nuno Alves, i3S & Rui Henrique, IPOP

Keynote Talk

14.15-15.00 Exosomes, other extracellular vesicles, and co-isolated factors in cross-talk between tumors and the immune system

Clotilde Théry, Institute Curie, Paris, France

15.00-15.30 Exosomes in Immune Suppression and Tumor Invasion

Wei Guo, University of Pennsylvania, Philadelphia, USA

15.30-16.00 Coffee Break

16.00-16.15 Selected Talk: Multiple myeloma-derived extracellular vesicles induce a T cell immunosuppressive bone marrow microenvironment

Raquel Lopes, Myeloma Lymphoma Research Group, Champalimaud Experimental Clinical Research Programme, Champalimaud Foundation, Lisbon, Portugal

16.15-16.45 Tumor agnostic dendritic cell vaccines

Michele DePalma, Swiss Cancer Center, Switzerland

16.45-17.00 Closing Session
Sónia Melo, i3S & Jorge Lima, i3S & André Albergaria