PORTO CANCER MEETING
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27th PORTO CANCER MEETING 2021
PORTO CANCER MEETING 2021 | MENU
Program
27th PORTO CANCER MEETING 2021
20 May
10.00-10.15 Welcome Session
Joana Paredes, i3S & Manuel Sobrinho-Simões, Ipatimup/ i3S & Claudio Sunkel, i3S
Session 1: Cancer Cell Heterogeneity & Plasticity
Chairs: José Carlos Machado, i3S & Carmen Jerónimo, IPOP
10.15-10.45 Breast cancer heterogeneity and resistance to endocrine therapy
Maria Vivanco
CIC bioGUNE, Basque Research & Technology Alliance (BRTA), Bilbao, Spain
10.45-11.15 Mechanisms regulating EMT tumor transition states
Ievgenia Pastushenko
Université Libre de Bruxelles (ULB), Bruxelles, Belgium
11.15-11.30 Selected Talk: Mutational landscape and Clonal Architecture of Oral Cancer
Inês Sequeira, Queen Mary University of London, London, United Kingdom
11.30-12.00 Tumor plasticity implications in breast cancer immunity
Toni Celià-Terrassa
Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
12.00-12.15 15-minutes Break
Special Session: Cancel_Stem Symposium
Chairs: Joana Paredes, i3S & Raquel Seruca, i3S
12.15-12.35 Using a humanized P-cadherin fly model to uncover key players involved in Cancer Stem-like Cell activity
Florence Janody
Instituto Gulbenkian Ciência (IGC), Oeiras & i3S, Porto
12.35-12.55 Gastric cancer stem cells identified by a SOX2 reporter system
Raquel Almeida
i3S, Porto, Portugal
2.55-13.15 Targeting drug combinations with nanomedicine-based strategies
João Nuno Moreira
Center for Neurosciences and Cell Biology (CNBC), Coimbra, Portugal
13.15-15.00 Lunch Break & Poster View
14.30-15.00 Satellite Seminar: Addressing the true complexity of cancer with 10x Genomics single cell and spatial multiomics
Session 2: Stemness & Tumor Microenvironment
Chairs: Ana Sofia Ribeiro, i3S & Maria José Oliveira, i3S
15.00-15.30 Mechano-perception in the tumour microenvironment
Chris Madsen
Cancer and Matrix Remodelling – Lund University, Lund, Sweden
15.30-16.00 Targeting the metastatic niche
Janine Erler
Biotech Research and Innovation Centre (BRIC), Copenhagen, Denmark
16.00-16.15 Selected Talk: Cancer-Stem cells exosomes coordinate intratumor communication and drive YAP1 activation
Carolina F. Ruivo, i3S, IPATIMUP; Institute of Biomedical Sciences Abel Salazar, Porto, Portugal
16.15-16.45 force-dependent regulation of stemness promotes tumor risk and aggression
Valerie Weaver
Centre for Bioengineering & Tissue Regeneration – UCSF, San Francisco, USA
21 May
Session 3: Invasion, Dissemination & Metastasis
Chairs: Joana Paredes, i3S & Cláudia Faria, IMM
9.30-10.00 Molecular mechanisms of cancer cell invasion: focus on P-cadherin and flotillins
Cécile Gauthier-Rouviére
CRBM, University of Montpellier – CNRS, Montpellier, France
10.00-10.15 Selected Talk: Osteosarcoma-derived secretome mimics the effects of a primary tumor during pre-metastatic niche formation
Sara Almeida, CIBIT/ICNAS – Institute for Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal
10.15-10.45 Heterogeneity of the Macro-Metastasis Parenchyma Interface (MMPI) during metastatic organ colonization and its impact on prognosis, pathophysiology and treatment
Tobias Pukrop
University Hospital Regensburg, Regensburg, Germany
10.45-11.00 Selected Talk: Ubiquitin Conjugating Enzymes promote aggressive metastatic brain disease and decrease patients’ survival
Eunice Paisana, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
11.00-11.15 15-minutes Break
11.15-11.45 Strategies to challenge brain metastasis lethality in mice and human
Manuel Valiente
Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
11.45-12.00 Selected Talk: Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis
Ana Sofia Ribeiro, i3S, IPATIMUP, Porto, Portugal
12.00-12.30 Biology and Vulnerabilities of Circulating Tumor Cells
Nicola Aceto
Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland
12.30-14.00 Lunch Break & Poster View
Session 4: Cancer Stemness – Clinical Translation
Chairs: Júlio Oliveira, IPOP & Ricardo Leão, FMUC
14.00-14.30 Replication repair deficiency, Obligatory mutation accumulation and its effect on cancer initiation and response to immunotherapy; Lessons from hereditary cancer syndromes
Uri Tabori
The Hospital for Sick Children
14.30-15.00 Targeting cancer stem cells in hormone resistance breast cancer
Bruno Simões
Division of Cancer Sciences, University of Manchester, UK
15.00-15.15 Selected Talk: Discovery of novel colon cancer stem cell inhibitors by high-throughput screening in tumour spheres
Marta Afonso, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal
15.15-15.45 Harnessing replication stress for novel breast cancer stem cell therapy
Christophe Ginestier
Cancer Research Center of Marseille (CRCM), Marseille, France
15.45-16.00 Award Communication & Closing Session
Joana Paredes, i3S & Jorge Lima, i3S & André Albergaria, i3S
