Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021

Uri Tabori

The Hospital for Sick Children, Toronto, Canada

“My clinical practice focuses on the treatment of children with cancer, with a particular focus on brain tumors and cancer predisposition. Based on my clinical experience, my research focuses on the development of systems for early detection, intervention and therapeutics in individuals highly predisposed to developing brain tumors. 

My team uses knowledge of syndromes predisposing to childhood cancer to examine early detection, interventions, and to develop novel therapies for these children. I have established an international bMMRD consortium to fulfil these aims and was able to develop surveillance and clinical protocols which saves lives (Aronson, Am J Gastro 2016). Actually, we found unique signatures of these cancers which can be exploited for therapy (Shlien, Nature Genet 2015, Bouffet, J Clin Oncol 2016). We are now using the power of our consortium and international scientists and physicians to uncover novel therapies which will transform the lives of these children worldwide.  The Tabori lab is focused on combining biological and translational research in paediatric oncology. Specifically, we are interested in studying mechanisms underlying brain tumor immortality and recurrence in the context of predisposition to cancer.

Currently our group is studying 3 major areas related to this concept:

1. Telomere maintenance and cancer recurrence

2. Cancer predisposition syndromes

3. Paediatric gliomas”