27th PORTO CANCER MEETING
Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021
Valerie M. Weaver
Centre for Bioengineering & Tissue Regeneration – UCSF San Francisco, USA
Valerie Weaver is a Professor in the Departments of Surgery, Bioengineering & Therapeutic Sciences and Radiation Oncology at UCSF, Director of the Center for Bioengineering and Tissue Regeneration and an active member of the Helen Diller Family Comprehensive Cancer Center and the Stem Cell Program at UCSF. Her laboratory conducts studies on the role of the extracellular matrix remodelling and integrin signalling in cancer biology with active programs in breast cancer development and metastasis as well as pancreatic cancer and glioblastoma. Valerie Weaver’s group was amongst the first to recognize ECM stiffness as a key regulator of tissue homeostasis and tumour evolution. This, and recent work from her lab recognizing the importance of cell-intrinsic and microenvironment mediated biochemical and biophysical cues in tissue development, tissue homeostasis and malignancy have challenged existing paradigms regarding the genetic and biochemical regulation of tissue homeostasis and cancer. Over the past 20 years, she has either led or participated in collaborative grants including multi-PI R01s, U01s and U54s and has co-authored multiple articles with collaborators within my own institution, throughout the USA and internationally.
Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM. Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005; 8:241-54. PMID: 16169468.
Levental, K.R., Yu, H., Kass, L., Lakins, J.N., Erler, J.T., Egeblad, M., Fong, S.F.T., Csiszar, K., Giaccia, A., Yamauchi, M., Wells, R., Gasser, D.L., and Weaver, V.M. Matrix Cross-linking forces tumour progression by enhancing integrin-dependent signalling. CELL, 139:1-16, 2009. PMID: 19931152; PMCID: PMC2788004.