Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021

Florence Janody

Cytoskeletal Regulation & Cancer, i3S, Porto, Portugal

Florence Janody performed her Ph.D. in Cell Biology, Structural Biology and Microbiology at the Developmental Biology Institute of Marseille Luminy (IBDML) in the laboratory of Dr. Nathalie Dostatni before joining the laboratory of Dr. Jessica Treisman for a Postdoctoral training at Skirball Institute in New York (USA) in 2000.  During these trainings, her main interest has been to understand how signal transduction cascades coordinate changes in gene expression. In a mosaic genetic screen for novel genes involved in signalling activity, she identified loss of function mutation for genes encoding Actin Binding Proteins (ABP). She established her independency in 2006 at Instituto Gulbenkian de Ciência (IGC) in Portugal. Her lab has reported that the actin cytoskeleton conveys signals from the cell membrane into intracellular signalling pathways, leading to cancer transcriptional programmes. She moved her lab in January 2018 to Instituto de Patologia e Imunologia Molecular da Universidade do Porto (Ipatimup)/ Instituto de Investigação e Inovação em Saúde (i3S) with the goal of deciphering the cytoskeletal rules governing carcinogenesis, focusing on signalling networks promoting aberrant cell plasticity properties, as these mechanisms underlie disease progression and therapeutic resistance, using the fruit fly Drosophila melanogaster; inducible human cell lines, tumour samples and computational modelling.