Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021
All indicated times are Lisbon/London time.

20 May

10.00-10.15 Welcome Session
Joana Paredes, i3S & Manuel Sobrinho-Simões, Ipatimup/ i3S & Claudio Sunkel, i3S

Session 1: Cancer Cell Heterogeneity & Plasticity

Chairs: José Carlos Machado, i3S & Carmen Jerónimo, IPOP

10.15-10.45 Breast cancer heterogeneity and resistance to endocrine therapy

Maria Vivanco
CIC bioGUNE, Basque Research & Technology Alliance (BRTA), Bilbao, Spain

10.45-11.15 Mechanisms regulating EMT tumor transition states

Ievgenia Pastushenko
Université Libre de Bruxelles (ULB), Bruxelles, Belgium

11.15-11.30 Selected Talk from Abstracts I

11.30-12.00 Tumor plasticity implications in breast cancer immunity

Toni Celià-Terrassa
Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain

12.00-12.15 15-minutes Break

Special Session: Cancel_Stem Symposium

Chairs: Joana Paredes, i3S & Raquel Seruca, i3S

12.15-12.35 Using a humanized P-cadherin fly model to uncover key players involved in Cancer Stem-like Cell activity

Florence Janody
Instituto Gulbenkian Ciência (IGC), Oeiras & i3S, Porto

12.35-12.55 Gastric cancer stem cells identified by a SOX2 reporter system

Raquel Almeida
i3S, Porto, Portugal

12.55-13.15 Targeting drug combinations with nanomedicine-based strategies

João Nuno Moreira
Center for Neurosciences and Cell Biology (CNBC), Coimbra, Portugal

13.15-15.00 Lunch Break & Poster View

14.30-15.00 Satellite Seminar: Addressing the true complexity of cancer with 10x Genomics single cell and spatial multiomics

Session 2: Stemness & Tumor Microenvironment

Chairs: Ana Sofia Ribeiro, i3S & Maria José Oliveira, i3S

15.00-15.30 Mechano-perception in the tumour microenvironment

Chris Madsen
Cancer and Matrix Remodelling – Lund University, Lund, Sweden

15.30-16.00 Targeting the metastatic niche

Janine Erler
Biotech Research and Innovation Centre (BRIC), Copenhagen, Denmark

16.00-16.15 Selected Talk from Abstracts II

16.15-16.45 Force-dependent regulation of stemness promotes tumor risk and aggression

Valerie Weaver
Centre for Bioengineering & Tissue Regeneration – UCSF, San Francisco, USA

21 May

Session 3: Invasion, Dissemination & Metastasis

Chairs: Joana Paredes, i3S & Cláudia Faria, IMM

9.30-10.00 Molecular mechanisms of cancer cell invasion : focus on P-cadherin and flotillins

Cécile Gauthier-Rouviére
CRBM, University of Montpellier – CNRS, Montpellier, France

10.00-10.15 Selected Talk from Abstracts III

10.15-10.45 Heterogeneity of the Macro-Metastasis Parenchyma Interface (MMPI) during metastatic organ colonization and its impact on prognosis, pathophysiology and treatment

Tobias Pukrop
University Hospital Regensburg, Regensburg, Germany

10.45-11.00 Selected Talk from Abstracts IV

11.00-11.15 15-minutes Break

11.15-11.45 Strategies to challenge brain metastasis lethality in mice and human

Manuel Valiente
Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

11.45-12.00 Selected Talk from Abstracts V

12.00-12.30 Biology and Vulnerabilities of Circulating Tumor Cells

Nicola Aceto
Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland

12.30-14.00 Lunch Break & Poster View

Session 4: Cancer Stemness – Clinical Translation

Chairs: Raquel Almeida, i3S, Júlio Oliveira, IPOP & Ricardo Leão, FMUC

14.00-14.30 Harnessing replication stress for novel breast cancer stem cell therapy

Christophe Ginestier
Cancer Research Center of Marseille (CRCM), Marseille, France

14.30-15.00 Targeting cancer stem cells in hormone resistance breast cancer

Bruno Simões
Division of Cancer Sciences, University of Manchester, UK

15.00-15.15 Selected Talk from Abstracts VI

15.15-15.45 Replication repair deficiency, Obligatory mutation accumulation and its effect on cancer initiation and response to immunotherapy; Lessons from hereditary cancer syndromes

Uri Tabori
The Hospital for Sick Children, Toronto, Canada

15.45-16.00 Award Communication & Closing Session
Joana Paredes, i3S & Jorge Lima, i3S & André Albergaria, i3S