27th PORTO CANCER MEETING
Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021
Université Libre de Bruxelles (ULB), Bruxelles, Belgium
Ievgenia Pastushenko is dermatologist specialised in dermato-oncology and surgery and a postdoc in the Laboratory of Prof. Cedric Blanpain at the Université Libre de Bruxelles (ULB) in Brussels, Belgium. During the postdoc, she focused her work on understanding the mechanisms regulating epithelial tumor heterogeneity and epithelial to mesenchymal plasticity. She discovered the tumor transition states occurring during tumor progression and identified the subpopulation of cells responsible for metastasis. Recently, Ievgenia uncovered that loss of function of FAT1, a gene frequently mutated across many human cancers, promotes hybrid epithelial to mesenchymal transition (EMT) and defined the precise molecular mechanisms underlying this phenotype.
Pastushenko I, Mauri F et al. Fat1 deletion promotes hybrid EMT state, tumor stemness and metastasis. Nature 2021. Pastushenko I et al. Identification of the tumor transition states occurring during EMT. Nature 2018.
Pastushenko I and Blanpain C. EMT transition states during tumor progression and metastasis. Review article. Trends Cell Biol 2019.