Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021

Cécile Gauthier-Rouvière

CRBM-CNRS, Monpellier, France

Cécile Gauthier-Rouvière is principal investigator at the Montpellier Cell Biology Research Center in France. Her research is focused on the molecular mechanisms driving cancer cell invasion. Her research projects use state-of-the-art cell biology approaches to identify new molecular mechanisms of cancer cell migration and invasion in order to provide new therapeutic options for cancer diagnosis, prognosis and therapy. She has published more than 50 papers in high impact factor cell biology journals, has more than 40 invitations to speak at international meetings (ASCB annual meeting, Gordon and FASEB research conferences) and was a former president of the french society for cell biology (SBCF).

Main recent publications:

P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration. Le Borgne-Rochet M, Angevin L, Bazellieres E, Ordas L, Comunale F, Denisov E, Tashireva L, Perelmuter V, Bieche I, Vacher S, Plutoni C, Seveno M, Bodin S, and Gauthier-Rouvière C (2019) Journal of Cell Science 132 :21.doi: 10.1242/jcs.233189. Research highlight, Journal of Cell Science 2019 132: e2104, Decorin connects ECM remodelling to collective cell migration

MT1-MMP targeting to endolysosomes is mediated by flotillin upregulation. Planchon D, Morris E, Genest M, Comunale F, Vacher S, Bièche I, Denisov E, Tashireva L, Perelmuter V, Linder S, Chavrier P, Bodin S, Gauthier- Rouvière C (2018) Journal of Cell Science 131: 17. doi: 10.1242/jcs.218925. Research highlight, Journal of Cell Science 2018 131: e1703.

Flotillins help deliver MT1-MMP in invasive cancers- Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion. Morris E, Bodin S, Delaval B, Comunale F, Georget V, Costa ML, Lutfalla G, Gauthier Rouvière C (2017) Biology of the Cell, 109:210- 221. doi: 10.1111/boc.201700001

P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces. Plutoni C, Bazellieres E, Le Borgne-Rochet M, Comunale F, Brugues A, Séveno M, Planchon D, Morin N, Bodin S, Trepat X and Gauthier-Rouvière C (2016) Journal of Cell Biology 212: 199-217. doi: 10.1083/jcb.201505105 Biosight P-cadherin provides the driving force for collective cell migration at http://jcb.rupress.org.gate1.inist.fr/site/biosights/biosights_jan_18_2016.xhtml

The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity. Thuault S, Comunale F, Hasna J, Fortier M, Planchon D, Elarouci N, De Reynies A, Bodin S, Blangy A, Gauthier-Rouvière C (2016) Molecular Biology of the Cell 27:2653-61. doi: 10.1091/mbc.E16-01-0041

P-cadherin-mediated Rho GTPase regulation during collective cell migration. Plutoni C, Bazellières E, Gauthier- Rouvière C (2016) Small GTPases May 6:1-8. (revue). doi: 10.1083/jcb.201505105