Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021

Bruno Simões

Breast Biology group, University of Manchester, UK

“I am a Research Fellow at the University of Manchester. The focus of my career has always been to understand the molecular mechanisms that govern normal and breast cancer stem cells. My ultimate goal is to translate basic discoveries to clinical applications that can in the long term contribute to a reduction in breast cancer mortality.

I obtained my degree in Microbial Biology and Genetics at the University of Lisbon, in 2004, after completing a Research Training in Pavia (Italy). My PhD studies were carried out in Bilbao (Spain) under the supervision of Dr Maria Vivanco and were mainly focused on analysing the effects of estrogen in human breast stem cells. In 2011, I joined the Breast Biology group led by Professor Rob Clarke, at the University of Manchester, and since then I have been investigating the role that breast cancer stem cells play in the acquisition of endocrine therapy resistance in estrogen receptor-positive tumours. I have also been working with Dr Sacha Howell in developing better chemoprevention approaches for women at risk of breast cancer since 2016.”