27th PORTO CANCER MEETING
Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021

Tobias Pukrop

University of Regensburg, Germany

Chairmen of the Comprehensive Cancer Center Ostbayern (CCCO) Head of the Interdisciplinary Center for systemic Tumor-therapy (ICT) and Early Clinical Trail Unit (ECTU).

Relevant work experience

Since 2015 W2-University Professor of Medical Oncology, University Regensburg,

2012 – 2014 Coordinator of the Göttinger-Comprehensive Cancer Center, University Medical Center Göttingen (UMG).

2011 Board certification of Palliative Care.

2008-2014 Senior physician at Department of Internal Medicine and Hematology/Oncology (UMG).

2008 Board certification of Internal Medicine and Hematology/Oncology 2001-2008 Resident physician at Dept. Hematology/Oncology (UMG).

Professional background

Since 2017 Member of DFG FOR2127: Selection and adaptation during metastatic cancer progression. (University Regensburg).

2013 – 2016 Member of BMBF eBio MetastaSys consortium (Regensburg/UMG).

2013 – 2016 Member of BMBF eBio e:Med: Molekulare Mechanismen in Malignen Lymphomen-(UMG/Regensburg).

2011 – 2015 Group leader of the UMG funded “Excellence Group-2011” title: „Factors of the carcinoma cells („seed“) and accessory cells of the brain („soil“) in cerebral metastasis.

2012 “Habilitation and Venia Legendi” in Internal Medicine (UMG).

2007 – 2014 Member of the DFG For942: WNT signaling in development and tumor progression.

2002 MD thesis, Dept. of Biochemistry University Ulm.

1994 – 2001 Studies of Medicine at the University of Ulm.

Main research focus

(CNS)-metastasis/colonization of solid cancer and aggressive Lymphoma.

Publications

1. Blazquez R, … Pukrop T: The macro-metastasis/organ parenchyma interface (MMPI) – A hitherto unnoticed area. Semin Cancer Biol. Oct 21. pii: S1044-579X(19) 30181-6. doi: 10.1016/j.semcancer.2019.10.012. (2019).

2. Blazquez R, … Pukrop T: LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer. Int J Cancer. Oct 18. doi: 10.1002/ijc.32742. (2019).

3. Doron H, … Pukrop T, Erez N: Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis. Cell Rep., Aug 13;28(7):1785-1798.e6. doi: 10.1016/j.celrep.2019.07.033 (2019).

4. Blazquez R, …, Pukrop T: PI3K: A master regulator of brain metastasis-promoting macrophages/microglia. Glia Nov;66(11):2438-2455 (2018).

5. Schwartz H, … Pukrop T, Erez N: Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation. Cancer Res. 76(15):4359-71 (2016).

Additional information

Spokesperson of the AK CNS malignancies of the DGHO, Member of the steering board CNS malignancies of the AIO

2014 Best Poster Award 4th Annual Brain Metastases Research and Emerging Therapy Conference of the EORTC meeting in Marseille.

2011 “Württembergischen Krebspreis 2010“ University Tübingen

2006 “Vincenz-Czerny-Award” of the German Society of Hematology/Oncology (DGHO) for oncological science.