Stemness & Metastasis: Advances in Research and Clinical Translation
20-21 May 2021

20 May

09.00-09.15 Welcome Session
Manuel Sobrinho-Simões, Ipatimup/ i3S & Claudio Sunkel, i3S

Session 1: Cancer Cell Heterogeneity & Plasticity

Chairs: José Carlos Machado, i3S & Ricardo Leão, FMUC

09.15-09.45 Stemness and EMT dynamics in tumor-intiating cells and metastasis

Toni Celià-Terrassa
Cancer Stem Cells & Metastasis Lab, Hospital del Mar Medical Research Institute (IMIM), Barcelona Biomedical Research Park (PRBB), Spain

09.45-10.15 Mechanisms regulating EMT tumor transition states

Ievgenia Pastushenko
Université Libre de Bruxelles (ULB), Bruxelles, Belgium

10.15-10.45 Coffee-break

10.45-11.15 Uri Tabori
The Hospital for Sick Children, Toronto, Canada

11.15-11.30 SELECTED TALK from abstracts

Special Session: Cancel_Stem Symposium

Chairs: Joana Paredes, i3S & Raquel Seruca, i3S

11.30-11.50 Florence Janody
Cytoskeletal Regulation & Cancer, i3S, Porto, Portugal

11.50-12.10 Raquel Almeida
i3S, Porto, Portugal

12.10-12.30 João Nuno Moreira
Center for Neurosciences and Cell Biology (CNBC), Coimbra, Portugal

12.30-13.30 Lunch

13.30-15.00 Speed Talks | Auditorium Mariano Gago

Chairs: Bruno Costa, ICVS & Bárbara Sousa, i3S

Session 2: Stemness & Tumor Microenvironment

Chairs: Maria Oliveira, i3S & Carmen Jerónimo, IPO-Porto

15.00-15.30 Dynamical approaches to decode EMT and stemness and their implications in phenotypic heterogeneity

Mohit K. Jolly
Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India

15.30-16.00 Valerie Weaver
Centre for Bioengineering & Tissue Regeneration – UCSF, San Francisco, USA

16.00-16.30 Coffee-break

16.30-17.00 Chris Madsen
Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University, Sweden

17.00-17.15 SELECTED TALK from abstracts

20.00 Meeting Dinner

21 May

Session 3: Invasion, Dissemination & Metastasis

Chairs: Ana Sofia Ribeiro, i3S & Cláudia Faria, IMM

09.00-09.30 Targeting the metastatic niche

Janine Erler
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark

09.30-10.00 Impact of the Macro-Metastasis Parenchyma Interface (MMPI) during metastatic organ colonization

Tobias Pukrop
University of Regensburg, Germany

10.00-10.30 Coffee Break

10.30-11.00 The brain microenvironment as a target of effective anti-metastasis strategies in mice and human

Manuel Valiente
Brain Metastasis Group, CNIO, Madrid, Spain

11.00-11.15 SELECTED TALK from abstracts

11.15-13.00 Speed Talks | Auditorium Mariano Gago

Chairs: João Vinagre, i3S & Joana Figueiredo, i3S

13.00-14.30 Lunch and Poster viewing

Session 4: Cancer Stemness – Clinical Translation

Chairs: Raquel Almeida, i3S & Júlio Oliveira, IPO-Porto

14.30-15.00 Christophe Ginestier
Epithelial Stem Cells and Cancer Lab, Cancer Research Center of Marseille, France

15.00-15.30 Cancer stem cells: on the crossroad of tumor radioresistance and metastases

Anna Dubrovska
Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany

15.30-16.00 Coffee-break

16.00-16.30 Targeting cancer stem cells in hormone resistance breast cancer

Bruno Simões
Breast Biology group, University of Manchester, UK

16.30-16.45 SELECTED TALK from abstracts

16.45-17.00 Closing Session
Joana Paredes, i3S, Jorge Lima, i3S & André Albergaria, i3S